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So she doesn’t seem wall-eyed 100% of the time.

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Background Pony #52EE
You’ll notice that her eyes start out in synch only to get more and more walled the more STRESS she’s under. You’ll also notice that most ponies get like that. The hypothesis that makes sense is that she’s something of a Type A personality who gets anxious about every little thing. She’s less Mortimer Snerd and more Arthur from PBS.
Yet One More Idiot
Artist -

World's biggest idiot xD
@ArrJaySketch  
Yeah, my dad developed his strabismus in infancy; he was first taken to an optician at about 3yo. In later childhood, they offered him the chance of surgery to repair the eye muscles and give him normal stereo vision, but the optician referred to the procedure as a “purely cosmetic” one (what, fixing double-vision is considered a cosmetic surgery? o_O), and being a young boy hearing the word “cosmetic” and thinking of girly make-up, he turned it down flat. O well. By the time he learnt of his mistake over the word in adulthood, they said it was too late to help him.
 
In my family, my dad has had strabismus and long sightedness (hyperopia) since infancy, my mum has had short-sightedness (myopia) since her early 30s, and my sister has developed astigmatism since her late 20s. All three now wear glasses, and I’m the only one who doesn’t (but I take regular biennial checkups just in case). The only problem I have is a case of stereoblindess, which even glasses can’t fix.
Background Pony #A649
My case was… well. My vision stopped fusing together so I just choose which my primary eye should be at a split second’s notice and the second eye becomes part of my periphery vision.
ArrJaySketch
My Little Pony - 1992 Edition
Thread Starter - Started a thread with over 100 pages
Wallet After Summer Sale -
Birthday Cake - Celebrated MLP's 7th birthday
Artist -
The End wasn't The End - Found a new home after the great exodus of 2012

@Yet_One_More_Idiot  
My strabismus onset when I was an adult. I learned to live with it, I think, and didn’t really realize I could do anything about it. My case was rather mild, though. Prism lenses are helping me a great deal! I had no idea how much stress it was causing me until I could actually see properly again.
 
About your dad: poor guy! Sounds awful! Sounds like he would have to have surgery to fix it. And it this point, I don’t blame him for not wanting to bother with it if it’s been this long. Interestingly, I found out my dad has a mild case of strabismus, too.
Background Pony #9E34
The fact that it happens constantly throughout the episode but nobody ever points it out or makes a big deal out of it is probably the best thing about the entire episode.
 
Derpy has goofy eyes and nobody cares.  
Just like Scootaloo.
Yet One More Idiot
Artist -

World's biggest idiot xD
As one with strabismus (misaligned eyes), I can force my eyes to focus temporarily, but they’ll become cross-eyed again without constant effort and attention. This also was super cute!
So true, I used to suffer from strabismus as a kid too, not to mention weak lenses. So I had glasses to correct my vision and a patch over my stronger eye to force me to focus my other eye in the correct direction. Think a cross between Brains from Thunderbirds, and a pirate. :P
 
That being said, it depends on the severity of the condition. My dad’s had strabismus all his life (he’s now retired at 63), and has his right eye permanently staring at the side of his nose, he can’t control it at all even for a little while.
Background Pony #43C6
At this moment I was just about to say: “Hey her eyes seem pretty straig…Oh nevermind :p”
ArrJaySketch
My Little Pony - 1992 Edition
Thread Starter - Started a thread with over 100 pages
Wallet After Summer Sale -
Birthday Cake - Celebrated MLP's 7th birthday
Artist -
The End wasn't The End - Found a new home after the great exodus of 2012

As one with strabismus (misaligned eyes), I can force my eyes to focus temporarily, but they’ll become cross-eyed again without constant effort and attention. This also was super cute!