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safe2267026 artist:bluse408 sci-twi32729 spike95130 spike the regular dog3291 twilight sparkle371229 dog14274 equestria girls267805 g42126393 my little pony equestria girls: rainbow rocks20403 adventure in the comments1354 angry38480 boots36626 clothes677830 collar51402 cute279968 doggy dragondox84 duality5767 feet57526 female1908465 glare9176 glasses95585 hallway1352 hand on hip14839 high heels18526 high res412922 hilarious in hindsight3902 lab coat3098 leash11127 legs12696 lockers2896 looking at each other38314 open mouth256864 sandals6323 self paradog10 self paradox4948 self ponidox10950 shirt45022 shoes65301 show accurate28224 signature49118 skirt60118 spikabetes3365 spike the dog3127 toes10194 twiabetes16191 twilight sparkle (alicorn)154820 twolight1651

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Background Pony #2F23
If the trailers (which, need I remind you, are just trailers) are of any indication then Science Twilight would be faced with a angry Twilight Prime (like Twilight’s Kingdom Part 2 angry).
Background Pony #E6E2
Human Twilight: I found you!
 
Twilight Prime: What do you want?
 
Human Twilight: Strange things are happening in this school and my readings point to myself as the culprit.
 
Twilight Prime: What’s going to happen to me now?
 
Human Twilight: We’re going to my lab… I have a present for you. Well it’s more like a medical procedure, actually it’s more like a medical experiment.