With twilight wondering of her alicorn powers after a party that led to applejack, rainbow dash, rarity and pinkie pie all had passed out.

Twilight notice that they walked across the desert in the movie and they want more cider

i think why fluttershy a not drink is for she will be drunk with only one strong alcohol cider! and she a not like what she get to the morning! think of the face of her friends learn twilight is immute to alcohol? i tnink is a good for twilight be immute to alcohol , with all the power she got , is will be very dangereuse for other if she lose control by be drunk! like ponyvilly be destroy by a drunk alicorn! is will be bad for her! ….oh? if alicorn are immute to alcohol is mean celestia a try drunk her self the day she seal her sister but never be drunk! man is sad for them for not be pass thier sadness in alcohol! like captien america! or the flash! both can drink and drink and not be drunk! give them the most strong alcohol and not be drunk!

Now somepony better check on RD fast before she chokes…

Alicorns have a liver like a horse as opposed to a pony. It takes a lot of alcohol to get a horse drunk.  

Fluttershy didn’t drink because she’s on an SSRI for anxiety, and that p[lays badly with alcohol.
 
At least that’s my theory (based on the fact that I have specifically been told to avoid alcohol while on an SSRI myself)

Super Solider Twilight Sparkle

Earth pony hardiness, right?

“I drink to forget, but I always remember…”

So Twilight is a Space Marine?

@Ryuki  
“On the bright side, now I’ll have someone to help me carry them home.”

@Psy-Psichinis  

 
That might be for the fact that Fluttershy didn’t drink alcohol with them, those 3 teacups on her table is the hint.
 
Also, she might be sighing over how her friends is a bunch of drunkard.

Now that some great cider!

At first I thought that Andy Price drew this, but then I looked again.  
Still, love the comical IDW style though. 😏  
(P.S. I’m surprised that Fluttershy is still awake just as much as Princess Twilight is…)

@Meanlucario  
As am I for that matter.

@Ebonysdagger  
So I’m one? Also, the joke is that Twi can out-drink everyone one else, with Flutters a background gag.

@Meanlucario  
A person who never drinks alcohol.  
@Background Pony #2587  
I’d say yes.

@Background Pony #2587  
A what?

So is the joke that Fluttershy is a teetotaler?

I guess she’s going to have to drink something stronger from now on. Like methanol.
 
Also, I’m curious to see the “waking up with a hangover” stage of this little party, and whether Twilight and Fluttershy have the strength to resist having a little fun (no, not that kind of fun, I mean silly, practical joke type stuff) with their passed out companions.

She out-drank AJ. Impressive.

This is quite brilliant

How cruel.

ohh well, make them alicorns.

“And ponies wonder why I don’t drink.”