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safe2273861 artist:thebrokencog1129 color edit9271 edit181084 spike95297 twilight sparkle372076 human270629 comic:the spike experiment19 g42132175 body swap916 breasts417291 busty twilight sparkle17377 clothes681776 colored27192 comic140988 dialogue100673 english4682 female1915965 humanized124706 letter4002 male588329 mirror7890 reading8596 speech bubble44410 straight190563 sweatdrop7516 thought bubble5951

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Background Pony #B99B
Later…
 
Twilight, in Spike’s body: “Spike, Spike! I’m home! I hope that whatever crazy antics we got into today when I switched our bodies doesn’t cause any lasting consequences. Well, for me at least… Rarity’s probably never going to speak to you/probably sue you, but… hey. All in the name of science, right? Spike? Spike?
 
(Twilight turns a corner and see herself, that being Spike in her body, standing there in disheveled clothes and with rumpled, wild hair.)
 
Twilight: Umm… Spike? W-What’s wrong?
 
Spike, in Twilight’s body: Twilight, while you were off ruining what little that I have that resembles a life with my body, I was conducting some experiments of my own.
 
(Twilight gasps!)
 
Twilight: “Spike, you… you didn’t!”
 
Spike: “Oh, yes… yes I did. I did something that totally changed the way I look at you… how I feel about you.”
 
Twilight: “Oh no! My actions had consequences!”
 
Spike: “Oh, they sure did Twilight… they sure did. And now that I’ve had your body at my fingertips all day, I’ve learned some… things. And we can never go back to the way it was before…”
 
Twilight, starting to cry: “Spike… you, you can’t mean…”
 
(Spike leans closer to his own body, hovering over Twilight as she often does to him.)
 
Spike: “Yes, Twilight… today, when I was alone in this castle, with your body at my command—
 
Twilight: “No… no, please!”
 
Spike “—I learned that your body is actually able to do physical work/chores/basic maintenance around here!
 
Twilight, sobbing: Nnnoooooo! My house of lies has fallen!
Background Pony #1667
@Spiritus Arcane  
Meh, I feel a magic potion that would drastically change one’s body to the opposite gender, sounds a bit more complicated that one that simply switches the minds of two, already existing, bodies.
Daneasaur
Lunar Supporter - Helped forge New Lunar Republic's freedom in the face of the Solar Empire's oppressive tyrannical regime (April Fools 2023).
Perfect Pony Plot Provider - Uploader of 10+ images with 350 upvotes or more (Questionable/Explicit)

Knowing how these comics tend to go, I’m betting the punchline will be that twilight accidentally scores with Rarity, thus humiliating spike for life.
 
I mean, I could be wrong, but I tend to be pessimistic when things concern spike.