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safe2282115 edit181554 edited screencap95981 screencap303171 spike95604 twilight sparkle373137 alicorn339222 dragon92805 pony1715598 g42138880 my little pony: friendship is magic268586 the last problem8134 break your own news177 breaking news205 female1924416 gigachad spike1341 husband and wife2660 implied rarity1771 king spike19 male591594 news483 older43785 older spike9934 older twilight4722 older twilight sparkle (alicorn)4190 princess twilight 2.04087 ship:twispike2178 shipping269071 straight191540 twilight sparkle (alicorn)155621 winged spike10763 wings254414
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Twiggy Spriggy

Spike the Chad who has been there for Twilight all his life or Flash the Virgin who’s only been in 1 episode.
I’d go for the Guy that gets shit done.
Background Pony #4683
@BlastTheChaos  
And I felt like they are relatable to one Soul Eater ship, Twilight is Maka, and Spike is Soul, Twispike can be Maka x Soul but in MLP:FiM.
Background Pony #4683
@Background Pony #D516  
Discord WAS also (S4), but he claimed Fluttershy and acted yandere over her (S5 onwards).  
Big Macintosh got owned by Starlight’s baker.  
Don’t forget Shining Armor… Nope…  
King Sombra is ded.
Background Pony #84EB
Twispike is the best straight ship involving Twilight of all, also around the top 5 of Spike’s heterosexual ships.
Background Pony Number 17
My Little Pony - 1992 Edition

@PonyPon  
They are related. Twilight hatched him, after all. And he grew up in her family as a sibling, even if half the time she treated him as her pet rather than her little brother.
 
It may not be a blood relation, but if MLP:FIM’s shown us anything, it’s that relationships based on friendship/love are just as valid as those based on bloodline.