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Background Pony #409F
@Drasvin
Blood and plasma are used for medicines to give to those who need it as well as for blood transfusion, and often with medicines, the patients’ immune systems aren’t working as well as they should. If the blood you give has a disease or certain medicines which can mess with detection of those diseases (HIV, HBV, + growth hormones from real people (mad cow)), then it can make their conditions worse and set them back. It’s also just a risk for contamination and disease spread. Plasma in particular needs these restrictions because it’s used for medicine for those who need plasma medicine, and a lot of those patients have immune system deficiencies.
DudeManGuy
The End wasn't The End - Found a new home after the great exodus of 2012

Waifu Hoarder
My best friend tried giving blood once, but they had to get rid of it because they found out that he had been to Ecuador, which is considered a high malaria risk location, a few months before. So he asked for them to give him his blood back. Naturally, they said no.
DudeManGuy
The End wasn't The End - Found a new home after the great exodus of 2012

Waifu Hoarder
@Dravsin  
Mixups are one huge reason to not do that. The possibility of error makes that an unfeasible idea and could lead to outbreaks.
Drasvin

I’ll give props to those that give blood, but I never could do it. I dislike needles, and the thought of my vital fluids being sucked out makes my skin crawl.  
A great cause, but…I just can’t.
 
@BronyHeresy That makes me wonder why they completely refuse diseased blood. True, it’s useless too most people, but as long as it doesn’t regularly mutate(like HIV) or doesn’t have an absurd number of variants, it should be okay-ish to administer to people that already have that disease. Just make sure to properly label the bags so you don’t get them mixed up, like with the blood type.
FeatherFoot

I gave blood earlier this year (back in March i believe?). I felt good about doing it.
 
And apparently I have O- blood, which coincidentially is the most needed blood type right now.
Deloreandudetommy
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I remember getting blood taken (they were giving me a blood test) and it both creeped the HECK out of me to see my blood going through the tube (the mere thought makes me lightheaded) and made me sing random nonsense in the highest pitched voice possible.
Background Pony #0357
I would, but I have AB blood type which is the worst donor type. Not to mention that in my country it’s not a rare blood type, so the hospitals have plenty of it…
DudeManGuy
The End wasn't The End - Found a new home after the great exodus of 2012

Waifu Hoarder
Ironically, after eight piercings, I’m still squeamish about shots and giving blood. Much less so than I used to be, but still.
Atiarotias
Speaking Fancy - For help with translations
The End wasn't The End - Found a new home after the great exodus of 2012

I don’t mind normal cut and bleeding, but still can’t stand looking at syringe or blood bags getting slowly (not that slow actually) filled up