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Background Pony #D3B9
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On the TV show “House, MD”, the characters will often go through a list of possible diagnoses for the patient of the week. Lupus is one that regularly gets ruled out from the start. Started as a meme, then used on the show itself as House himself realized it’s never lupus.
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V - In Dr.House the medics always say that it might be Lupus, to which House responds “It’s never Lupus.”  
Also, in one episode he hid pills inside a book on Lupus, Foreman (I think) said:  
“You stash your drugs on a Lupus textbook.”  
“It’s never Lupus.”