Background Pony #490D
I’m impressed by the amount of effort going into the background. That is a hell of a lot of memes.
Tetrominon
Solar Supporter - Fought against the New Lunar Republic rebellion on the side of the Solar Deity (April Fools 2023).
Non-Fungible Trixie -
Bronze Bit -
Speaking Fancy - For helping with translations
Happy Derpy! -

Undesirable
We kill the Batman.
V_for_Vodka

You may take our friendships, but you’ll never take our memes!
Background Pony #D92B
You’re treding on thin ice, purple horse.
Tragiclady
Not a Llama - Happy April Fools Day!
Friendship, Art, and Magic (2017) - Celebrated Derpibooru's five year anniversary with friends.

While I likely enjoyed memes better back when I didn’t know what they actually were, I’m sure at least some decent fanart, jokes, and discussions have come from them as a result.
 
Except for the “Sunset yells at Twilight” meme. (I’m only saying that because I’m biased).
 
@RustleRustle  
Whichever group of people that learned to communicate complex feelings in Pepe the Frog and Wojack images must have been geniuses :D
RustleRustle
Solar Supporter - Fought against the New Lunar Republic rebellion on the side of the Solar Deity (April Fools 2023).
Verified Pegasus - Show us your gorgeous wings!
Preenhub - We all know what you were up to this evening~
Wallet After Summer Sale -
Birthday Cake - Celebrated MLP's 7th birthday
Artist -

Battybattybattybatty-
You can’t have my memes! Get ’em, Pepe!  
full  
REEEEEEEEEEEEE
FanOfMostEverything
Derpy! - For Patreon supporters
Cool Crow - "Caw!" An awesome tagger
Magnificent Metadata Maniac - #1 Assistant
Lunar Supporter - Helped forge New Lunar Republic's freedom in the face of the Solar Empire's oppressive tyrannical regime (April Fools 2023).
Non-Fungible Trixie -
Preenhub - We all know what you were up to this evening~
My Little Pony - 1992 Edition
Silver Bit -
Ruby -
Wallet After Summer Sale -

Planeswalker — FoME
That isn’t how memes work, Book Horse.
thestralpony

All your memes are belong to Twilight! lol
SuperSupermario24
My Little Pony - 1992 Edition
Wallet After Summer Sale -
Not a Llama - Happy April Fools Day!

fluffy sylveon
NEVER