@Solitude  

You know i have never thought of this, but Pinkie could play the Comedian. This seems dissatisfying though because the Comedian dies, and Pinkie Pie is (almost) best pony.

@Background Pony #6C2E  
Harry Dresden.

The Emperor vs Gandalf  
Who will win in a fight ?

@Blewberry  
Oh, Trixie as Manehattan. Hmm.
 
“And what is this cutie mark? Atoms, atomic power or some such? I don’t like it.  
“If I am to have a cutie mark it shall be one I respect…”
 
It is explained that the alicorn role has been chosen for me because of the impact it will have on Celestia’s enemies. They are shaping me into something gaudy… something lethal.

Surprised at all the downvotes on this one… it’s a joke, people.

If you mean the original Watchmen pony trailer, yeah. Naturally, it would have to have a lot of psychoanalysis of the ponies. Per the following article, it would be interesting to see how Alan Moore would handle FiM:
 
www.nerdcenaries.com/alan-moore-announced-as-new-showrunner-of-my-little-pony-friendship-is-magic/
 
Ok so if Twi = Manhattan, Dash = an aging, impotent, secretly nerdy Nite Owl?  
Or vice versa?  
Fluttershy = Silk Spectre and Pinkie = Rorschach? Or vice versa?  
(this is like an eye test, lol)  
Rarity = Ozymandias, that one is easy.  
AJ = Comedian because she’s a hard-working American pony?

@Ponyweed  
There’s an amazing Watchmen trailer parody by Bronyvids on youtube, that might help inspire you, check it out!
 
Also, if you wanted to fully ponify it, Trixie as Manehattan would work great!

@Blewberry  
I’d like to do a Mane 6 / Watchmen crossover, but it’s difficult to get the Mane 6 to line up precisely with the Masks.
 
If Twi were playing Manhattan for instance (teleportation powers too, ahem) who would Dash be / be paired up against?
 
Re: addressing him as Jon. Good point… I don’t think it affects the delivery of the line though, since it’s alicorn Twi addressing Dr. Manhattan and not playing Dr. Manhattan.  
It would be easy to make the edit if I ever bother to recreate this panel from scratch.

@Background Pony #CC2A  
“My failsafe spell failed. But only because this episode’s plot called for it.”

OP, To present the line properly you’d have to use Jon, not Dr Manhattan, since Manhattan addressed Ozymandias as Adrian in this situation.
 
@Ponyweed  
Manhattan destroys anything ever.  
I think Pinkie could legitimately take Comedian,  
I’d agree on fluttershy and rorschach.  
Also, why have you left out Dashy? Dashy is the destroyer.

I’m not some sort of cartoon pony, Ozymandias. Do you really think I would reveal my master-stroke if you had even the slightest chance of affecting its outcome? I designed the dresses 35 minutes ago.
 

 
Nostalgia Perfume was just a clever front. Even as we speak, my holding companies in the East Whindies are buying up vast quantities of Veidt Inc. stock…
 
Soon they will be churning out blind bags, outfits, My Little Pony-themed designer apparel!
 
Your only triumph? Failing to prevent the future of the My Little Pony Franchise from taking over the human race.

The most pathetic thing about that Manhattan guy is that he’s perfectly duplicable.

@soundtea To be fair, it was G1 Starscream. He’s a gloaty dumbfuck. He’d be more dangerous than PrimeScream IF he acted like PrimeScream. But he’s a bit of a baby.
 
 
@Ponyweed  
Rarity would have wrapped his bomb in some silly magical fabric that couldn’t be broken before she even confronted him. The bombs just go {FOOB} and nothing happens.  
Exception: If Ozymandias asked Sweetie Belle for a scarf prior, she’ll have used just enough material to make the shell unstable. GJ Dumb Belle you killed everypony.

@soundtea  
Simple. The writers pull something so Twilight can win despite how completely unplausible it actually is.

It is a humorous premise. That being said, that’s what I like about MLP :) I could easily imagine Twilight Sparkle learning a spell to rearrange herself after being disintegrated. She already has a spell to disintegrate others o_o;

@Princess♠Molestia  
Only if John has already foreseen his destroying her. Of course, if there’s a tachyon haze, then all bets are off.

@Ponyweed  
The others I can possibly believe.
 
But you have a hard time convincing me that any of the alicorns can take on someone who can literally blow a person into chunky giblets with a simple thought.

@Ponyweed  
Watch out, we got a badass over here

@soundtea  
Oh shit man, it is ON  
 
Twilight vs. Manhattan? Twilight.  
Fluttershy vs. Rorschach? Rorschach is friends to the animals.  
They would share their love of pretty butterflies.  
Pinkie Pie vs. Nite Owl? They would console each other about their insecurities.  
Applejack vs. Comedian? No fight, they go for beer.  
Rarity vs. Ozymandias? Rarity.

well shes fucked.

Damn homie

Mmm. Yep. Twilight’s toast. Nice knowin’ ya purple smart.